[HTML][HTML] IL-33 promotes ST2-dependent lung fibrosis by the induction of alternatively activated macrophages and innate lymphoid cells in mice
D Li, R Guabiraba, AG Besnard, M Komai-Koma… - Journal of Allergy and …, 2014 - Elsevier
Background The initiation and regulation of pulmonary fibrosis are not well understood. IL-
33, an important cytokine for respiratory diseases, is overexpressed in the lungs of patients
with idiopathic pulmonary fibrosis. Objectives We aimed to determine the effects and
mechanism of IL-33 on the development and severity of pulmonary fibrosis in murine
bleomycin-induced fibrosis. Methods Lung fibrosis was induced by bleomycin in wild-type or
Il33r (St2)−/− C57BL/6 mice treated with the recombinant mature form of IL-33 or anti–IL-33 …
33, an important cytokine for respiratory diseases, is overexpressed in the lungs of patients
with idiopathic pulmonary fibrosis. Objectives We aimed to determine the effects and
mechanism of IL-33 on the development and severity of pulmonary fibrosis in murine
bleomycin-induced fibrosis. Methods Lung fibrosis was induced by bleomycin in wild-type or
Il33r (St2)−/− C57BL/6 mice treated with the recombinant mature form of IL-33 or anti–IL-33 …