A bioinformatics approach identifies signal transducer and activator of transcription-3 and checkpoint kinase 1 as upstream regulators of kidney injury molecule-1 after …
AK Ajay, TM Kim, V Ramirez-Gonzalez… - Journal of the …, 2014 - journals.lww.com
Abstract Kidney injury molecule-1 (KIM-1)/T cell Ig and mucin domain-containing protein-1
(TIM-1) is upregulated more than other proteins after AKI, and it is highly expressed in renal
damage of various etiologies. In this capacity, KIM-1/TIM-1 acts as a phosphatidylserine
receptor on the surface of injured proximal tubular epithelial cells, mediating phagocytosis of
apoptotic cells, and it may also act as a costimulatory molecule for immune cells. Despite
recognition of KIM-1 as an important therapeutic target for kidney disease, the regulators of …
(TIM-1) is upregulated more than other proteins after AKI, and it is highly expressed in renal
damage of various etiologies. In this capacity, KIM-1/TIM-1 acts as a phosphatidylserine
receptor on the surface of injured proximal tubular epithelial cells, mediating phagocytosis of
apoptotic cells, and it may also act as a costimulatory molecule for immune cells. Despite
recognition of KIM-1 as an important therapeutic target for kidney disease, the regulators of …