Distinct macrophage phenotypes contribute to kidney injury and repair

S Lee, S Huen, H Nishio, S Nishio, HK Lee… - Journal of the …, 2011 - journals.lww.com
The ischemically injured kidney undergoes tubular cell necrosis and apoptosis,
accompanied by an interstitial inflammatory cell infiltrate. In this study, we show that iNos-
positive proinflammatory (M1) macrophages are recruited into the kidney in the first 48 hours
after ischemia/reperfusion injury, whereas arginase 1–and mannose receptor–positive,
noninflammatory (M2) macrophages predominate at later time points. Furthermore,
depletion of macrophages before ischemia/reperfusion diminishes kidney injury, whereas …