Basophils exhibit antibacterial activity through extracellular trap formation
Allergy, 2015•Wiley Online Library
Basophils are primarily associated with immunomodulatory functions in allergic diseases
and parasitic infections. Recently, it has been demonstrated that both activated human and
mouse basophils can form extracellular DNA traps (BET s) containing mitochondrial DNA
and granule proteins. In this report, we provide evidence that, in spite of an apparent lack of
phagocytic activity, basophils can kill bacteria through BET formation.
and parasitic infections. Recently, it has been demonstrated that both activated human and
mouse basophils can form extracellular DNA traps (BET s) containing mitochondrial DNA
and granule proteins. In this report, we provide evidence that, in spite of an apparent lack of
phagocytic activity, basophils can kill bacteria through BET formation.
Abstract
Basophils are primarily associated with immunomodulatory functions in allergic diseases and parasitic infections. Recently, it has been demonstrated that both activated human and mouse basophils can form extracellular DNA traps (BETs) containing mitochondrial DNA and granule proteins. In this report, we provide evidence that, in spite of an apparent lack of phagocytic activity, basophils can kill bacteria through BET formation.
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