Lung surfactant proteins A and D as pattern recognition proteins

P Waters, M Vaid, U Kishore, T Madan - Target pattern recognition in …, 2009 - Springer
Target pattern recognition in innate immunity, 2009Springer
Lung surfactant proteins A and D belong to a group ofsoluble humoral pattern recognition
receptors, called collectins, which modulate the immune response to microorganisms. They
bind essential carbohydrate and lipid antigens found on the surface of microorganisms via
low affinity C-type lectin domains and regulate the host's response by binding to immune cell
surface receptors. They form multimeric structures that bind, agglutinate, opsonise and
neutralize many different pathogenic microorganisms including bacteria, yeast, fungi and …
Abstract
Lung surfactant proteins A and D belong to a group ofsoluble humoral pattern recognition receptors, called collectins, which modulate the immune response to microorganisms.
They bind essential carbohydrate and lipid antigens found on the surface of microorganisms via low affinity C-type lectin domains and regulate the host's response by binding to immune cell surface receptors. They form multimeric structures that bind, agglutinate, opsonise and neutralize many different pathogenic microorganisms including bacteria, yeast, fungi and viruses. They modulate the uptake ofthese microorganisms by phagocytic cells as well as both the inflammatory and the adaptive immune responses. Recent data have also highlighted their involvement in clearance of apoptotic cells, hypersensitivity and a number of lung diseases.
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