Design of clinical trials in AKI: a report from an NIDDK workshop. Trials of patients with sepsis and in selected hospital settings

BA Molitoris, MD Okusa, PM Palevsky… - Clinical Journal of the …, 2012 - journals.lww.com
AKI remains an important clinical problem, with a high mortality rate, increasing incidence,
and no Food and Drug Administration-approved therapeutics. Advances in addressing this
clinical need require approaches for rapid diagnosis and stratification of injury, development
of therapeutic agents based on precise understanding of key pathophysiological events, and
implementation of well designed clinical trials. In the near future, AKI biomarkers may
facilitate trial design. To address these issues, the National Institute of Diabetes and …