[HTML][HTML] Endothelin-1 induces serine phosphorylation of the adaptor protein p66Shc and its association with 14-3-3 protein in glomerular mesangial cells

M Foschi, F Franchi, J Han, G La Villa… - Journal of Biological …, 2001 - ASBMB
Endothelin-1 (ET-1) is a vasoconstrictor peptide known to be a potent mitogen for glomerular
mesangial cells (GMC). In the current study, it is demonstrated that ET-1 treatment of GMC
results in serine phosphorylation of the 66-kDa isoform of the adapter protein Shc (p66 Shc).
ET-1-induced serine phosphorylation of p66 Shc requires activation of the mitogen-activated
protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) signaling module and is
efficiently inhibited by both a MAPK/ERK kinase (MEK)-selective inhibitor and adenovirus …