[HTML][HTML] Hydrogen peroxide generation induces pp60src activation in human platelets: evidence for the involvement of this pathway in store-mediated calcium entry
Reactive oxygen species, such as H 2 O 2, have been recognized as intracellular
messengers involved in several cell functions. Here we report the activation of the tyrosine
kinase pp60 src by H 2 O 2, a mechanism required for the activation of store-mediated Ca 2+
entry (SMCE) in human platelets. Treatment of platelets with H 2 O 2 resulted in a time-and
concentration-dependent activation of pp60 src. Incubation with GF 109203X, a protein
kinase C (PKC) inhibitor, prevented H 2 O 2-induced pp60 src activation. In contrast …
messengers involved in several cell functions. Here we report the activation of the tyrosine
kinase pp60 src by H 2 O 2, a mechanism required for the activation of store-mediated Ca 2+
entry (SMCE) in human platelets. Treatment of platelets with H 2 O 2 resulted in a time-and
concentration-dependent activation of pp60 src. Incubation with GF 109203X, a protein
kinase C (PKC) inhibitor, prevented H 2 O 2-induced pp60 src activation. In contrast …