Influence of leptin in the development of hepatic fibrosis produced in mice by Schistosoma mansoni infection and by chronic carbon tetrachloride administration
JJ Potter, L Rennie-Tankesley, E Mezey - Journal of hepatology, 2003 - Elsevier
Background/Aims: Leptin, a product of the obese (ob) gene is present in activated stellate
cells. This study investigated whether leptin is essential for the development of hepatic
fibrosis caused by various agents. Methods: Control and ob/ob mice were infected with
Schistosoma mansoni or were administered chronic carbon tetrachloride to cause hepatic
fibrosis. Results: Fibrosis developed in both ob/ob and control mice. However, the amount of
histologically detectable fibrosis and the increase in liver hydroxyproline content was …
cells. This study investigated whether leptin is essential for the development of hepatic
fibrosis caused by various agents. Methods: Control and ob/ob mice were infected with
Schistosoma mansoni or were administered chronic carbon tetrachloride to cause hepatic
fibrosis. Results: Fibrosis developed in both ob/ob and control mice. However, the amount of
histologically detectable fibrosis and the increase in liver hydroxyproline content was …