[HTML][HTML] Bi-directional regulation of brown fat adipogenesis by the insulin receptor
AJ Entingh, CM Taniguchi, CR Kahn - Journal of Biological Chemistry, 2003 - ASBMB
Insulin is a potent inducer of adipogenesis, and differentiation of adipocytes requires many
components of the insulin signaling pathway, including the insulin receptor substrate IRS-1
and phosphatidylinositol 3-kinase (PI3K). Brown pre-adipocytes in culture exhibit low levels
of insulin receptor (IR), and during differentiation there is both an increase in total IR levels
and a shift in the alternatively spliced forms of IR from the A isoform (–exon 11) to the B
isoform (+ exon 11). Brown pre-adipocyte cell lines from insulin receptor-deficient mice …
components of the insulin signaling pathway, including the insulin receptor substrate IRS-1
and phosphatidylinositol 3-kinase (PI3K). Brown pre-adipocytes in culture exhibit low levels
of insulin receptor (IR), and during differentiation there is both an increase in total IR levels
and a shift in the alternatively spliced forms of IR from the A isoform (–exon 11) to the B
isoform (+ exon 11). Brown pre-adipocyte cell lines from insulin receptor-deficient mice …