[HTML][HTML] Dystrophin-Glycoprotein Complex: Post-translational Processing and Dystroglycan Function* 210
DE Michele, KP Campbell - Journal of Biological Chemistry, 2003 - ASBMB
The dystrophin-glycoprotein complex (DGC) 1 is a multimeric transmembrane protein
complex first isolated from skeletal muscle membranes (1). The central protein of the DGC is
dystroglycan (Fig. 1). In addition to skeletal muscle, dystroglycan is strongly expressed in
heart and smooth muscle, as well as many non-muscle tissues including brain and
peripheral nerve. In vertebrates, dystroglycan is generated from a single gene (DAG1),
which is cleaved into a peripheral α-dystroglycan protein and a transmembrane ß …
complex first isolated from skeletal muscle membranes (1). The central protein of the DGC is
dystroglycan (Fig. 1). In addition to skeletal muscle, dystroglycan is strongly expressed in
heart and smooth muscle, as well as many non-muscle tissues including brain and
peripheral nerve. In vertebrates, dystroglycan is generated from a single gene (DAG1),
which is cleaved into a peripheral α-dystroglycan protein and a transmembrane ß …