[HTML][HTML] Systematic Structure-Function Analysis of Androgen Receptor Leu701 Mutants Explains the Properties of the Prostate Cancer Mutant L701H 2
DJ van de Wijngaart, M Molier, SJ Lusher… - Journal of biological …, 2010 - ASBMB
One mechanism of prostate tumors for escape from androgen ablation therapies is mutation
of the androgen receptor (AR). We investigated the unique properties of the AR L701H
mutant, which is strongly stimulated by cortisol, by a systematic structure-function analysis.
Most amino acid substitutions at position 701 did not affect AR activation by 5α-
dihydrotestosterone. Further analysis of the AR Leu 701 variants showed that AR L701M
and AR L701Q, like AR L701H, had changed ligand responsiveness. AR L701M was …
of the androgen receptor (AR). We investigated the unique properties of the AR L701H
mutant, which is strongly stimulated by cortisol, by a systematic structure-function analysis.
Most amino acid substitutions at position 701 did not affect AR activation by 5α-
dihydrotestosterone. Further analysis of the AR Leu 701 variants showed that AR L701M
and AR L701Q, like AR L701H, had changed ligand responsiveness. AR L701M was …