Coordinated regulation of myeloid cells by tumours

DI Gabrilovich, S Ostrand-Rosenberg… - Nature Reviews …, 2012 - nature.com
Nature Reviews Immunology, 2012nature.com
Myeloid cells are the most abundant nucleated haematopoietic cells in the human body and
are a collection of distinct cell populations with many diverse functions. The three groups of
terminally differentiated myeloid cells—macrophages, dendritic cells and granulocytes—are
essential for the normal function of both the innate and adaptive immune systems. Mounting
evidence indicates that the tumour microenvironment alters myeloid cells and can convert
them into potent immunosuppressive cells. Here, we consider myeloid cells as an intricately …
Abstract
Myeloid cells are the most abundant nucleated haematopoietic cells in the human body and are a collection of distinct cell populations with many diverse functions. The three groups of terminally differentiated myeloid cells — macrophages, dendritic cells and granulocytes — are essential for the normal function of both the innate and adaptive immune systems. Mounting evidence indicates that the tumour microenvironment alters myeloid cells and can convert them into potent immunosuppressive cells. Here, we consider myeloid cells as an intricately connected, complex, single system and we focus on how tumours manipulate the myeloid system to evade the host immune response.
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