Activated intestinal macrophages in patients with cirrhosis release NO and IL-6 that may disrupt intestinal barrier function
J Du Plessis, H Vanheel, CEI Janssen, L Roos… - Journal of …, 2013 - Elsevier
BACKGROUND & AIMS: Bacterial infections commonly occur in decompensated cirrhosis
resulting from bacterial translocation from the intestine. We studied the role of intestinal
macrophages and the epithelial barrier in cirrhosis. METHODS: Forty-four patients with
NASH/ASH cirrhosis (decompensated n= 29, compensated n= 15) and nineteen controls
undergoing endoscopy were recruited. Serum was obtained and LPS and LBP levels
determined. Intestinal macrophages were characterized by flow cytometry …
resulting from bacterial translocation from the intestine. We studied the role of intestinal
macrophages and the epithelial barrier in cirrhosis. METHODS: Forty-four patients with
NASH/ASH cirrhosis (decompensated n= 29, compensated n= 15) and nineteen controls
undergoing endoscopy were recruited. Serum was obtained and LPS and LBP levels
determined. Intestinal macrophages were characterized by flow cytometry …