Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis.

Q Wang, T Stacy, M Binder… - Proceedings of the …, 1996 - National Acad Sciences
Q Wang, T Stacy, M Binder, M Marin-Padilla, AH Sharpe, NA Speck
Proceedings of the National Academy of Sciences, 1996National Acad Sciences
The CBFA2 (AML1) gene encodes a DNA-binding subunit of the heterodimeric core-binding
factor. The CBFA2 gene is disrupted by the (8; 21),(3; 21), and (12; 21) chromosomal
translocations associated with leukemias and myelodysplasias in humans. Mice lacking a
CBF alpha 2 protein capable of binding DNA die between embryonic days 11.5 and 12.5
due to hemorrhaging in the central nervous system (CNS), at the nerve/CNS interfaces of
cranial and spinal nerves, and in somitic/intersomitic regions along the presumptive spinal …
The CBFA2 (AML1) gene encodes a DNA-binding subunit of the heterodimeric core-binding factor. The CBFA2 gene is disrupted by the (8;21), (3;21), and (12;21) chromosomal translocations associated with leukemias and myelodysplasias in humans. Mice lacking a CBF alpha 2 protein capable of binding DNA die between embryonic days 11.5 and 12.5 due to hemorrhaging in the central nervous system (CNS), at the nerve/CNS interfaces of cranial and spinal nerves, and in somitic/intersomitic regions along the presumptive spinal cord. Hemorrhaging is preceded by symmetric, bilateral necrosis in these regions. Definitive erythropoiesis and myelopoiesis do not occur in Cbfa2-deficient embryos, and disruption of one copy of the Cbfa2 gene significantly reduces the number of progenitors for erythroid and myeloid cells.
National Acad Sciences