γ-IFN induces a differential expression of HLA-DR, DQ and DP antigens on peripheral blood myeloid leukemic blasts at various stages of differentiation

M Lecchi, E Lovisone, C Genetta, D Peruccio… - Leukemia research, 1989 - Elsevier
Using specific monoclonal antibodies and the indirect immunofluorescence technique,
peripheral blood myeloid leukemic blasts from 49 patients were studied for DR expression,
42 for DQ and nine for DP after four days of culture without and with gamma-IFN. The
expression of class II molecules on untreated cells dependent upon the stage of
differentiation and was maximal for DR antigens and lower for DP, while DQ was present
only in a small percentage of M2, M4 or M5 blasts. M3 blasts lacked both DR and DQ …