Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH

F Caballero, A Fernández, AM De Lacy… - Journal of …, 2009 - Elsevier
BACKGROUND/AIMS: Non-alcoholic fatty liver disease (NAFLD) pathogenesis remains
unknown. Due to the emerging role of free cholesterol (FC) in NAFLD, our aim was to
examine the correlation between FC accumulation in patients with NAFLD and the
expression of enzymes that regulate cholesterol homeostasis. METHODS: Filipin staining,
indicative of FC accumulation, and real-time PCR analyses were performed in 31 NAFLD
patients and in seven controls. RESULTS: All NASH patients (n= 14) and 4 out of 17 patients …