[HTML][HTML] Overcoming memory T-cell responses for induction of delayed tolerance in nonhuman primates
Y Yamada, S Boskovic, A Aoyama, T Murakami… - American Journal of …, 2012 - Elsevier
The presence of alloreactive memory T cells is a major barrier for induction of tolerance in
primates. In theory, delaying conditioning for tolerance induction until after organ
transplantation could further decrease the efficacy of the regimen, since preexisting
alloreactive memory T cells might be stimulated by the transplanted organ. Here, we show
that such “delayed tolerance” can be induced in nonhuman primates through the mixed
chimerism approach, if specific modifications to overcome/avoid donor-specific memory T …
primates. In theory, delaying conditioning for tolerance induction until after organ
transplantation could further decrease the efficacy of the regimen, since preexisting
alloreactive memory T cells might be stimulated by the transplanted organ. Here, we show
that such “delayed tolerance” can be induced in nonhuman primates through the mixed
chimerism approach, if specific modifications to overcome/avoid donor-specific memory T …