Use of toxicogenomics to understand mechanisms of drug-induced hepatotoxicity during drug discovery and development
EAG Blomme, Y Yang, JF Waring - Toxicology letters, 2009 - Elsevier
Hepatotoxicity is a common cause of failure in drug discovery and development and is also
frequently the source of adverse drug reactions. Therefore, a better prediction,
characterization and understanding of drug-induced hepatotoxicity could result in safer
drugs and a more efficient drug discovery and development process. Among the 'omics
technologies, toxicogenomics (or the use of gene expression profiling in toxicology)
represents an attractive approach to predict toxicity and to gain a mechanistic understanding …
frequently the source of adverse drug reactions. Therefore, a better prediction,
characterization and understanding of drug-induced hepatotoxicity could result in safer
drugs and a more efficient drug discovery and development process. Among the 'omics
technologies, toxicogenomics (or the use of gene expression profiling in toxicology)
represents an attractive approach to predict toxicity and to gain a mechanistic understanding …
