Cyclophosphamide disrupts hepatic sinusoidal endothelium and improves transplanted cell engraftment in rat liver
H Malhi, S Slehria, B Joseph, KK Bhargava… - Hepatology, 2002 - Elsevier
To determine whether disruption of the hepatic sinusoidal endothelium will facilitate
engraftment of transplanted cells, we treated Fischer 344 (F344) rats lacking dipeptidyl
peptidase IV (DPPIV) activity with cyclophosphamide (CP). Electron microscopy showed
endothelial injury within 6 hours following CP, and, after 24 and 48 hours, the endothelium
was disrupted in most hepatic sinusoids. CP did not affect Kupffer cell function. Similarly, CP
had no obvious effects on hepatocytes. Intrasplenic transplantation of F344 rat hepatocytes …
engraftment of transplanted cells, we treated Fischer 344 (F344) rats lacking dipeptidyl
peptidase IV (DPPIV) activity with cyclophosphamide (CP). Electron microscopy showed
endothelial injury within 6 hours following CP, and, after 24 and 48 hours, the endothelium
was disrupted in most hepatic sinusoids. CP did not affect Kupffer cell function. Similarly, CP
had no obvious effects on hepatocytes. Intrasplenic transplantation of F344 rat hepatocytes …
