Alteration of mitochondrial proteome due to activation of Notch1 signaling pathway
NP Basak, A Roy, S Banerjee - Journal of Biological Chemistry, 2014 - ASBMB
The Notch signaling pathway, a known regulator of cell fate decisions, proliferation, and
apoptosis, has recently been implicated in the regulation of glycolysis, which affects tumor
progression. However, the impact of Notch on other metabolic pathways remains to be
elucidated. To gain more insights into the Notch signaling and its role in regulation of
metabolism, we studied the mitochondrial proteome in Notch1-activated K562 cells using a
comparative proteomics approach. The proteomic study led to the identification of 10 unique …
apoptosis, has recently been implicated in the regulation of glycolysis, which affects tumor
progression. However, the impact of Notch on other metabolic pathways remains to be
elucidated. To gain more insights into the Notch signaling and its role in regulation of
metabolism, we studied the mitochondrial proteome in Notch1-activated K562 cells using a
comparative proteomics approach. The proteomic study led to the identification of 10 unique …
