Adenovirus sensing by the immune system
S Atasheva, DM Shayakhmetov - Current opinion in virology, 2016 - Elsevier
Highlights•Soluble blood factors interact with adenovirus capsid and activate NF-κB-
dependent signaling.•Macrophages activate proinflammatory response by sensing viral
entry and intracellular viral DNA.•DNA damage response machinery senses double-strand
DNA ends of adenovirus genome and triggers viral replication arrest.The host immune
system developed multiple ways for recognition of viral pathogens. Upon disseminated
adenovirus infection, the immune system senses adenovirus invasion from the moment it …
dependent signaling.•Macrophages activate proinflammatory response by sensing viral
entry and intracellular viral DNA.•DNA damage response machinery senses double-strand
DNA ends of adenovirus genome and triggers viral replication arrest.The host immune
system developed multiple ways for recognition of viral pathogens. Upon disseminated
adenovirus infection, the immune system senses adenovirus invasion from the moment it …