[HTML][HTML] The polycomb repressive complex 1 protein BMI1 is required for constitutive heterochromatin formation and silencing in mammalian somatic cells
M Abdouh, R Hanna, J El Hajjar, A Flamier… - Journal of Biological …, 2016 - ASBMB
The polycomb repressive complex 1 (PRC1), containing the core BMI1 and RING1A/B
proteins, mono-ubiquitinylates histone H2A (H2A ub) and is associated with silenced
developmental genes at facultative heterochromatin. It is, however, assumed that the PRC1
is excluded from constitutive heterochromatin in somatic cells based on work performed on
mouse embryonic stem cells and oocytes. We show here that BMI1 is required for
constitutive heterochromatin formation and silencing in human and mouse somatic cells …
proteins, mono-ubiquitinylates histone H2A (H2A ub) and is associated with silenced
developmental genes at facultative heterochromatin. It is, however, assumed that the PRC1
is excluded from constitutive heterochromatin in somatic cells based on work performed on
mouse embryonic stem cells and oocytes. We show here that BMI1 is required for
constitutive heterochromatin formation and silencing in human and mouse somatic cells …
