Calcium restores a normal proliferation phenotype in human polycystic kidney disease epithelial cells
T Yamaguchi, SJ Hempson, GA Reif… - Journal of the …, 2006 - journals.lww.com
Polycystic kidney disease (PKD) is a lethal disorder characterized by progressive expansion
of renal cysts. Genetic mutations associated with PKD are thought to disrupt intracellular Ca
2+ regulation, leading to abnormal proliferation of tubule epithelial cells. cAMP stimulates
the B-Raf/MEK/extracellular signal-regulated kinase (B-Raf/MEK/ERK) pathway and
accelerates the proliferation of cells that are cultured from PKD cysts. By contrast, cAMP
inhibits the proliferation of cells from normal human kidneys (NHK) and M-1 mouse …
of renal cysts. Genetic mutations associated with PKD are thought to disrupt intracellular Ca
2+ regulation, leading to abnormal proliferation of tubule epithelial cells. cAMP stimulates
the B-Raf/MEK/extracellular signal-regulated kinase (B-Raf/MEK/ERK) pathway and
accelerates the proliferation of cells that are cultured from PKD cysts. By contrast, cAMP
inhibits the proliferation of cells from normal human kidneys (NHK) and M-1 mouse …
