[HTML][HTML] The low density lipoprotein receptor-related protein LRP is regulated by membrane type-1 matrix metalloproteinase (MT1-MMP) proteolysis in malignant cells
DV Rozanov, E Hahn-Dantona, DK Strickland… - Journal of Biological …, 2004 - ASBMB
We demonstrate that the presentation of LRP and the subsequent uptake of its ligands by
malignant cells are both strongly regulated by MT1-MMP. Because LRP is essential for the
clearance of multiple ligands, these findings have important implications for many
pathophysiological processes including the pericellular proteolysis in neoplastic cells as
well as the fate of the soluble matrix-degrading proteases such as MMP-2. MT1-MMP is a
key protease in cell invasion and a physiological activator of MMP-2. Cellular LRP consists …
malignant cells are both strongly regulated by MT1-MMP. Because LRP is essential for the
clearance of multiple ligands, these findings have important implications for many
pathophysiological processes including the pericellular proteolysis in neoplastic cells as
well as the fate of the soluble matrix-degrading proteases such as MMP-2. MT1-MMP is a
key protease in cell invasion and a physiological activator of MMP-2. Cellular LRP consists …
