A mouse model of vascularized heterotopic spleen transplantation for studying spleen cell biology and transplant immunity
JJ Wang, L Qiu, R Fernandez, XY Yeap, CX Lin… - JoVE (Journal of …, 2019 - jove.com
The spleen is a unique lymphoid organ that plays a critical role in the homeostasis of the
immune and hematopoietic systems. Patients that have undergone splenectomy regardless
of precipitating causes are prone to develop an overwhelming post-splenectomy infection
and experience increased risks of deep venous thrombosis and malignancies. Recently,
epidemiological studies indicated that splenectomy might be associated with the occurrence
of cardiovascular diseases, suggesting that physiological functions of the spleen have not …
immune and hematopoietic systems. Patients that have undergone splenectomy regardless
of precipitating causes are prone to develop an overwhelming post-splenectomy infection
and experience increased risks of deep venous thrombosis and malignancies. Recently,
epidemiological studies indicated that splenectomy might be associated with the occurrence
of cardiovascular diseases, suggesting that physiological functions of the spleen have not …