The gut microbiota contributes to a mouse model of spontaneous bile duct inflammation
E Schrumpf, M Kummen, L Valestrand, TU Greiner… - Journal of …, 2017 - Elsevier
Background & Aims A strong association between human inflammatory biliary diseases and
gut inflammation has led to the hypothesis that gut microbes and lymphocytes activated in
the intestine play a role in biliary inflammation. The NOD. c3c4 mouse model develops
spontaneous biliary inflammation in extra-and intrahepatic bile ducts. We aimed to clarify the
role of the gut microbiota in the biliary disease of NOD. c3c4 mice. Methods We sampled
cecal content and mucosa from conventionally raised (CONV-R) NOD. c3c4 and NOD …
gut inflammation has led to the hypothesis that gut microbes and lymphocytes activated in
the intestine play a role in biliary inflammation. The NOD. c3c4 mouse model develops
spontaneous biliary inflammation in extra-and intrahepatic bile ducts. We aimed to clarify the
role of the gut microbiota in the biliary disease of NOD. c3c4 mice. Methods We sampled
cecal content and mucosa from conventionally raised (CONV-R) NOD. c3c4 and NOD …