Comparison of evidence of treatment effects in randomized and nonrandomized studies
ContextThere is substantial debate about whether the results of nonrandomized studies are
consistent with the results of randomized controlled trials on the same topic. ObjectivesTo
compare results of randomized and nonrandomized studies that evaluated medical
interventions and to examine characteristics that may explain discrepancies between
randomized and nonrandomized studies. Data SourcesMEDLINE (1966–March 2000), the
Cochrane Library (Issue 3, 2000), and major journals were searched. Study SelectionForty …
consistent with the results of randomized controlled trials on the same topic. ObjectivesTo
compare results of randomized and nonrandomized studies that evaluated medical
interventions and to examine characteristics that may explain discrepancies between
randomized and nonrandomized studies. Data SourcesMEDLINE (1966–March 2000), the
Cochrane Library (Issue 3, 2000), and major journals were searched. Study SelectionForty …