Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-β signaling* 210
X Lin, M Liang, XH Feng - Journal of Biological Chemistry, 2000 - ASBMB
Smads are important intracellular signaling effectors for transforming growth factor-β (TGF-β)
and related factors. Proper TGF-β signaling requires precise control of Smad functions. In
this study, we have identified a novel HECT class ubiquitin E3 ligase, designated Smurf2,
that negatively regulates Smad2 signaling. In both yeast two-hybrid and in vitro binding
assays, we found that Smurf2 could interact with receptor-activated Smads (R-Smads),
including Smad1, Smad2, and Smad3 but not Smad4. Ectopic expression of Smurf2 was …
and related factors. Proper TGF-β signaling requires precise control of Smad functions. In
this study, we have identified a novel HECT class ubiquitin E3 ligase, designated Smurf2,
that negatively regulates Smad2 signaling. In both yeast two-hybrid and in vitro binding
assays, we found that Smurf2 could interact with receptor-activated Smads (R-Smads),
including Smad1, Smad2, and Smad3 but not Smad4. Ectopic expression of Smurf2 was …
