Effects of levodopa on regional cerebral metabolism and blood flow
JH Ko, RP Lerner, D Eidelberg - Movement Disorders, 2015 - Wiley Online Library
JH Ko, RP Lerner, D Eidelberg
Movement Disorders, 2015•Wiley Online LibraryLevodopa (l‐dopa) has been at the forefront of antiparkinsonian therapy for a half century.
Recent advances in functional brain imaging have contributed substantially to the
understanding of the effects of l‐dopa and other dopaminergic treatment on the activity of
abnormal motor and cognitive brain circuits in Parkinson's disease patients. Progress has
also been made in understanding the functional pathology of dyskinesias, a common side
effect of l‐dopa treatment, at both regional and network levels. Here, we review these …
Recent advances in functional brain imaging have contributed substantially to the
understanding of the effects of l‐dopa and other dopaminergic treatment on the activity of
abnormal motor and cognitive brain circuits in Parkinson's disease patients. Progress has
also been made in understanding the functional pathology of dyskinesias, a common side
effect of l‐dopa treatment, at both regional and network levels. Here, we review these …
Abstract
Levodopa (l‐dopa) has been at the forefront of antiparkinsonian therapy for a half century. Recent advances in functional brain imaging have contributed substantially to the understanding of the effects of l‐dopa and other dopaminergic treatment on the activity of abnormal motor and cognitive brain circuits in Parkinson's disease patients. Progress has also been made in understanding the functional pathology of dyskinesias, a common side effect of l‐dopa treatment, at both regional and network levels. Here, we review these studies, focusing mainly on the new mechanistic insights provided by metabolic brain imaging and network analysis. © 2014 International Parkinson and Movement Disorder Society
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