Cortical cholinergic function is more severely affected in parkinsonian dementia than in Alzheimer disease: an in vivo positron emission tomographic study
Background Pathology reports have shown that cholinergic forebrain neuronal losses in
parkinsonian dementia (PDem) are equal to or greater than those in Alzheimer disease
(AD). We hypothesized that patients with PDem would have cholinergic deficits that were
similar to or greater than those of patients with AD. Objective To determine in vivo cortical
acetylcholinesterase (AChE) activity in healthy control subjects and in patients with mild AD,
PDem, and Parkinson disease without dementia using AChE positron emission tomography …
parkinsonian dementia (PDem) are equal to or greater than those in Alzheimer disease
(AD). We hypothesized that patients with PDem would have cholinergic deficits that were
similar to or greater than those of patients with AD. Objective To determine in vivo cortical
acetylcholinesterase (AChE) activity in healthy control subjects and in patients with mild AD,
PDem, and Parkinson disease without dementia using AChE positron emission tomography …
