Objective To assess regions and patterns of brain atrophy in patients with Parkinson disease
(PD) with normal cognition (PD-NC), mild cognitive impairment (PD-MCI), and dementia-
level cognitive deficits (PDD). Design Images were quantified using a region-of-interest
approach and voxel-based morphometry analysis. We used a high-dimensional pattern
classification approach to delineate brain regions that collectively formed the Spatial Pattern
of Abnormalities for Recognition of PDD. Setting The Parkinson's Disease and Movement …