Background Parkinson's disease (PD), characterized by motor dysfunction and cognitive
decline, may demonstrate specific patterns of brain atrophy. Although cross-sectional
magnetic resonance imaging (MRI) studies show correlation between regional brain volume
loss and cognitive impairment, there is only scarce evidence from longitudinal studies
validating the link between cognition and brain anatomy in PD. Objective To test the
relationship between magnitude and spatial extent of atrophy in PD patients with …