Tissue-specific metabolic regulation of FOXO-binding protein: FOXO does not act alone
N Kodani, J Nakae - Cells, 2020 - mdpi.com
N Kodani, J Nakae
Cells, 2020•mdpi.comThe transcription factor forkhead box (FOXO) controls important biological responses,
including proliferation, apoptosis, differentiation, metabolism, and oxidative stress
resistance. The transcriptional activity of FOXO is tightly regulated in a variety of cellular
processes. FOXO can convert the external stimuli of insulin, growth factors, nutrients,
cytokines, and oxidative stress into cell-specific biological responses by regulating the
transcriptional activity of target genes. However, how a single transcription factor regulates a …
including proliferation, apoptosis, differentiation, metabolism, and oxidative stress
resistance. The transcriptional activity of FOXO is tightly regulated in a variety of cellular
processes. FOXO can convert the external stimuli of insulin, growth factors, nutrients,
cytokines, and oxidative stress into cell-specific biological responses by regulating the
transcriptional activity of target genes. However, how a single transcription factor regulates a …
The transcription factor forkhead box (FOXO) controls important biological responses, including proliferation, apoptosis, differentiation, metabolism, and oxidative stress resistance. The transcriptional activity of FOXO is tightly regulated in a variety of cellular processes. FOXO can convert the external stimuli of insulin, growth factors, nutrients, cytokines, and oxidative stress into cell-specific biological responses by regulating the transcriptional activity of target genes. However, how a single transcription factor regulates a large set of target genes in various tissues in response to a variety of external stimuli remains to be clarified. Evidence indicates that FOXO-binding proteins synergistically function to achieve tightly controlled processes. Here, we review the elaborate mechanism of FOXO-binding proteins, focusing on adipogenesis, glucose homeostasis, and other metabolic regulations in order to deepen our understanding and to identify a novel therapeutic target for the prevention and treatment of metabolic disorders.
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