[HTML][HTML] Studies on LXR-and FXR-mediated effects on cholesterol homeostasis in normal and cholic acid-depleted mice
J Wang, C Einarsson, C Murphy, P Parini… - Journal of lipid …, 2006 - ASBMB
As previously reported by us, mice with targeted disruption of the CYP8B1 gene
(CYP8B1−/−) fail to produce cholic acid (CA), upregulate their bile acid synthesis, reduce the
absorption of dietary cholesterol and, after cholesterol feeding, accumulate less liver
cholesterol than wild-type (CYP8B1+/+) mice. In the present study, cholesterol-enriched diet
(0.5%) or administration of a synthetic liver X receptor (LXR) agonist strongly upregulated
CYP7A1 expression in CYP8B1−/− mice, compared to CYP8B1+/+ mice. Cholesterol-fed …
(CYP8B1−/−) fail to produce cholic acid (CA), upregulate their bile acid synthesis, reduce the
absorption of dietary cholesterol and, after cholesterol feeding, accumulate less liver
cholesterol than wild-type (CYP8B1+/+) mice. In the present study, cholesterol-enriched diet
(0.5%) or administration of a synthetic liver X receptor (LXR) agonist strongly upregulated
CYP7A1 expression in CYP8B1−/− mice, compared to CYP8B1+/+ mice. Cholesterol-fed …
