[HTML][HTML] Non-invasive stratification of hepatocellular carcinoma risk in non-alcoholic fatty liver using polygenic risk scores
C Bianco, O Jamialahmadi, S Pelusi, G Baselli… - Journal of …, 2021 - Elsevier
Background & Aims Hepatocellular carcinoma (HCC) risk stratification in individuals with
dysmetabolism is a major unmet need. Genetic predisposition contributes to non-alcoholic
fatty liver disease (NAFLD). We aimed to exploit robust polygenic risk scores (PRS) that can
be evaluated in the clinic to gain insight into the causal relationship between NAFLD and
HCC, and to improve HCC risk stratification. Methods We examined at-risk individuals
(NAFLD cohort, n= 2,566; 226 with HCC; and a replication cohort of 427 German patients …
dysmetabolism is a major unmet need. Genetic predisposition contributes to non-alcoholic
fatty liver disease (NAFLD). We aimed to exploit robust polygenic risk scores (PRS) that can
be evaluated in the clinic to gain insight into the causal relationship between NAFLD and
HCC, and to improve HCC risk stratification. Methods We examined at-risk individuals
(NAFLD cohort, n= 2,566; 226 with HCC; and a replication cohort of 427 German patients …