Chronic treatment with fluvoxamine desensitizes 5-HT2C receptor-mediated hypolocomotion in rats
M Yamauchi, T Tatebayashi, K Nagase… - Pharmacology …, 2004 - Elsevier
The effectiveness of fluvoxamine, a selective serotonin re-uptake inhibitor (SSRI), in the
treatment of anxiety disorders, such as obsessive-compulsive, panic and social anxiety
disorders, has been confirmed in clinical studies. The hypersensitivity of 5-HT2C receptors
has been reported in subjects with these disorders, and SSRIs have been suggested to
have therapeutic effects in such cases through the desensitization of the 5-HT2C receptor
function. In the present study, we investigated whether chronic administration of fluvoxamine …
treatment of anxiety disorders, such as obsessive-compulsive, panic and social anxiety
disorders, has been confirmed in clinical studies. The hypersensitivity of 5-HT2C receptors
has been reported in subjects with these disorders, and SSRIs have been suggested to
have therapeutic effects in such cases through the desensitization of the 5-HT2C receptor
function. In the present study, we investigated whether chronic administration of fluvoxamine …