[HTML][HTML] DAP12 stabilizes the C-terminal fragment of the triggering receptor expressed on myeloid cells-2 (TREM2) and protects against LPS-induced pro …
L Zhong, XF Chen, ZL Zhang, Z Wang, XZ Shi… - Journal of Biological …, 2015 - ASBMB
Triggering receptor expressed on myeloid cells 2 (TREM2) is a DAP12-associated receptor
expressed in microglia, macrophages, and other myeloid-derived cells. Previous studies
have suggested that TREM2/DAP12 signaling pathway reduces inflammatory responses
and promotes phagocytosis of apoptotic neurons. Recently, TREM2 has been identified as a
risk gene for Alzheimer disease (AD). Here, we show that DAP12 stabilizes the C-terminal
fragment of TREM2 (TREM2-CTF), a substrate for γ-secretase. Co-expression of DAP12 with …
expressed in microglia, macrophages, and other myeloid-derived cells. Previous studies
have suggested that TREM2/DAP12 signaling pathway reduces inflammatory responses
and promotes phagocytosis of apoptotic neurons. Recently, TREM2 has been identified as a
risk gene for Alzheimer disease (AD). Here, we show that DAP12 stabilizes the C-terminal
fragment of TREM2 (TREM2-CTF), a substrate for γ-secretase. Co-expression of DAP12 with …
