Association of lifetime cognitive engagement and low β-amyloid deposition
SM Landau, SM Marks, EC Mormino… - Archives of …, 2012 - jamanetwork.com
Objective To assess the association between lifestyle practices (cognitive and physical
activity) and β-amyloid deposition, measured with positron emission tomography using
carbon 11–labeled Pittsburgh Compound B ([11 C] PiB), in healthy older individuals. Design
Cross-sectional clinical study. Setting Berkeley, California. Participants Volunteer sample of
65 healthy older individuals (mean age, 76.1 years), 10 patients with Alzheimer disease
(AD)(mean age, 74.8 years), and 11 young controls (mean age, 24.5 years) were studied …
activity) and β-amyloid deposition, measured with positron emission tomography using
carbon 11–labeled Pittsburgh Compound B ([11 C] PiB), in healthy older individuals. Design
Cross-sectional clinical study. Setting Berkeley, California. Participants Volunteer sample of
65 healthy older individuals (mean age, 76.1 years), 10 patients with Alzheimer disease
(AD)(mean age, 74.8 years), and 11 young controls (mean age, 24.5 years) were studied …