Beta-catenin signaling in murine liver zonation and regeneration: a Wnt-Wnt situation!
J Yang, LE Mowry, KN Nejak-Bowen, H Okabe… - Hepatology, 2014 - journals.lww.com
Liver-specific β-catenin knockout (β-Catenin-LKO) mice have revealed an essential role of β-
catenin in metabolic zonation where it regulates pericentral gene expression and in initiating
liver regeneration (LR) after partial hepatectomy (PH), by regulating expression of Cyclin-
D1. However, what regulates β-catenin activity in these events remains an enigma. Here we
investigate to what extent β-catenin activation is Wnt-signaling-dependent and the potential
cell source of Wnts. We studied liver-specific Lrp5/6 KO (Lrp-LKO) mice where Wnt-signaling …
catenin in metabolic zonation where it regulates pericentral gene expression and in initiating
liver regeneration (LR) after partial hepatectomy (PH), by regulating expression of Cyclin-
D1. However, what regulates β-catenin activity in these events remains an enigma. Here we
investigate to what extent β-catenin activation is Wnt-signaling-dependent and the potential
cell source of Wnts. We studied liver-specific Lrp5/6 KO (Lrp-LKO) mice where Wnt-signaling …