[HTML][HTML] Glutamine and asparagine activate mTORC1 independently of Rag GTPases
D Meng, Q Yang, H Wang, CH Melick, R Navlani… - Journal of Biological …, 2020 - ASBMB
Nutrient sensing by cells is crucial, and when this sensing mechanism is disturbed, human
disease can occur. mTOR complex 1 (mTORC1) senses amino acids to control cell growth,
metabolism, and autophagy. Leucine, arginine, and methionine signal to mTORC1 through
the well-characterized Rag GTPase signaling pathway. In contrast, glutamine activates
mTORC1 through a Rag GTPase–independent mechanism that requires ADP-ribosylation
factor 1 (Arf1). Here, using several biochemical and genetic approaches, we show that eight …
disease can occur. mTOR complex 1 (mTORC1) senses amino acids to control cell growth,
metabolism, and autophagy. Leucine, arginine, and methionine signal to mTORC1 through
the well-characterized Rag GTPase signaling pathway. In contrast, glutamine activates
mTORC1 through a Rag GTPase–independent mechanism that requires ADP-ribosylation
factor 1 (Arf1). Here, using several biochemical and genetic approaches, we show that eight …