Background Synaptic loss is an early pathological event in Alzheimer's disease (AD), but its
underlying molecular mechanisms remain largely unknown. Recently, microRNAs (miRNAs)
have emerged as important modulators of synaptic function and memory. Methods We used
miRNA array and quantitative polymerase chain reaction to examine the alteration of
miRNAs in AD mice and patients as well as the Morris water maze to evaluate learning and
memory in the mice. We also used adeno-associated virus or lentivirus to introduce tyrosine …