[HTML][HTML] MicroRNA-339-5p down-regulates protein expression of β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) in human primary brain cultures and is …
Alzheimer disease (AD) results, in part, from the excess accumulation of the amyloid-β (Aβ)
peptide as neuritic plaques in the brain. The short Aβ peptide is derived from the large
transmembrane Aβ precursor protein (APP). The rate-limiting step in the production of Aβ
from APP is mediated by the β-site APP-cleaving enzyme 1 (BACE1). Dysregulation of
BACE1 levels leading to excess Aβ deposition is implicated in sporadic AD. Thus,
elucidating the full complement of regulatory pathways that control BACE1 expression is key …
peptide as neuritic plaques in the brain. The short Aβ peptide is derived from the large
transmembrane Aβ precursor protein (APP). The rate-limiting step in the production of Aβ
from APP is mediated by the β-site APP-cleaving enzyme 1 (BACE1). Dysregulation of
BACE1 levels leading to excess Aβ deposition is implicated in sporadic AD. Thus,
elucidating the full complement of regulatory pathways that control BACE1 expression is key …