The level of NPY receptor mRNA expression in diet-induced obese and resistant mice

XF Huang, M Han, LH Storlien - Molecular Brain Research, 2003 - Elsevier
Some mice become obese whereas others remain lean when raised on a high-energy diet.
This study examined the levels of neuropeptide Y (NPY), and of Y1, Y2, Y5 and leptin
receptor mRNA expression in the hypothalamic arcuate nucleus (Arc) of chronic high-energy
diet-induced obese (DIO) and resistant (DR) mice. Forty mice were divided into two groups
and fed either a high-fat (HF: 40% of calories from fat, 20% of calories from saturated fat; n=
34) or low-fat (LF: 10% of calories from fat, 1% from saturated fat; n= 6) diet. After 22 weeks …