[HTML][HTML] Morphologic and immunophenotypical features distinguishing Merkel cell polyomavirus-positive and negative Merkel cell carcinoma
T Kervarrec, A Tallet, E Miquelestorena-Standley… - Modern Pathology, 2019 - Elsevier
In 2008, Feng et al. identified Merkel cell polyomavirus integration as the primary oncogenic
event in~ 80% of Merkel cell carcinoma cases. The remaining virus-negative Merkel cell
carcinoma cases associated with a high mutational load are most likely caused by UV
radiation. The current study aimed to compare the morphological and immunohistochemical
features of 80 virus-positive and 21 virus-negative Merkel cell carcinoma cases. Microscopic
evaluation revealed that elongated nuclei—similar to the spindle-shape variant of small cell …
event in~ 80% of Merkel cell carcinoma cases. The remaining virus-negative Merkel cell
carcinoma cases associated with a high mutational load are most likely caused by UV
radiation. The current study aimed to compare the morphological and immunohistochemical
features of 80 virus-positive and 21 virus-negative Merkel cell carcinoma cases. Microscopic
evaluation revealed that elongated nuclei—similar to the spindle-shape variant of small cell …