Overexpression of miR-10a and miR-375 and downregulation of YAP1 in medullary thyroid carcinoma
J Hudson, E Duncavage, A Tamburrino… - … and molecular pathology, 2013 - Elsevier
MicroRNAs are a primordial mechanism of gene expression control that appear to be crucial
to cellular development and may play an important role in tumor development. Much is
known about the genetics of medullary thyroid carcinomas, as approximately 25% are
hereditary and harbor germ line activating mutations in the RET gene. Somatic RET
mutations are also seen in roughly 50% of sporadic medullary thyroid carcinomas. Few
studies, however, have evaluated the role of microRNA expression in these tumors. DNA …
to cellular development and may play an important role in tumor development. Much is
known about the genetics of medullary thyroid carcinomas, as approximately 25% are
hereditary and harbor germ line activating mutations in the RET gene. Somatic RET
mutations are also seen in roughly 50% of sporadic medullary thyroid carcinomas. Few
studies, however, have evaluated the role of microRNA expression in these tumors. DNA …