[HTML][HTML] Carbon tetrachloride-mediated lipid peroxidation induces early mitochondrial alterations in mouse liver
L Knockaert, A Berson, C Ribault, PE Prost… - Laboratory …, 2012 - Elsevier
Abstract Although carbon tetrachloride (CCl 4)-induced acute and chronic hepatotoxicity
have been extensively studied, little is known about the very early in vivo effects of this
organic solvent on oxidative stress and mitochondrial function. In this study, mice were
treated with CCl 4 (1.5 ml/kg ie 2.38 g/kg) and parameters related to liver damage, lipid
peroxidation, stress/defense and mitochondria were studied 3 h later. Some CCl 4-
intoxicated mice were also pretreated with the cytochrome P450 2E1 inhibitor …
have been extensively studied, little is known about the very early in vivo effects of this
organic solvent on oxidative stress and mitochondrial function. In this study, mice were
treated with CCl 4 (1.5 ml/kg ie 2.38 g/kg) and parameters related to liver damage, lipid
peroxidation, stress/defense and mitochondria were studied 3 h later. Some CCl 4-
intoxicated mice were also pretreated with the cytochrome P450 2E1 inhibitor …