Effect of hydrocortisone on mortality and organ support in patients with severe COVID-19: the REMAP-CAP COVID-19 corticosteroid domain randomized clinical trial
Importance Evidence regarding corticosteroid use for severe coronavirus disease 2019
(COVID-19) is limited. Objective To determine whether hydrocortisone improves outcome for
patients with severe COVID-19. Design, Setting, and Participants An ongoing adaptive
platform trial testing multiple interventions within multiple therapeutic domains, for example,
antiviral agents, corticosteroids, or immunoglobulin. Between March 9 and June 17, 2020,
614 adult patients with suspected or confirmed COVID-19 were enrolled and randomized …
(COVID-19) is limited. Objective To determine whether hydrocortisone improves outcome for
patients with severe COVID-19. Design, Setting, and Participants An ongoing adaptive
platform trial testing multiple interventions within multiple therapeutic domains, for example,
antiviral agents, corticosteroids, or immunoglobulin. Between March 9 and June 17, 2020,
614 adult patients with suspected or confirmed COVID-19 were enrolled and randomized …