Initial failures of anti-tau antibodies in Alzheimer's disease are reminiscent of the amyloid-β story
BP Imbimbo, C Balducci, S Ippati… - Neural regeneration …, 2023 - journals.lww.com
Tau is an important protein of the central nervous system formed by 352–441 amino acids
and encoded by the MAPT (microtubule-associated protein tau) gene on chromosome 17
which generates 6 isoforms. Tau is located in axons, dendrites, nucleus, cell membrane, and
synapses of neurons. The protein is also expressed to a lesser extent in astrocytes and
oligodendrocytes, although its role in these cells has been little investigated. The protein is
also present in the interstitial fluid and can cross into the cerebrospinal fluid (CSF) and reach …
and encoded by the MAPT (microtubule-associated protein tau) gene on chromosome 17
which generates 6 isoforms. Tau is located in axons, dendrites, nucleus, cell membrane, and
synapses of neurons. The protein is also expressed to a lesser extent in astrocytes and
oligodendrocytes, although its role in these cells has been little investigated. The protein is
also present in the interstitial fluid and can cross into the cerebrospinal fluid (CSF) and reach …
