Aging is a complex process that differentially impacts multiple cognitive, sensory, neuronal
and molecular processes. Technological innovations now allow for parallel investigation of
neuronal circuit function, structure and molecular composition in the brain of awake
behaving adult mice. Thus, mice have become a critical tool to better understand how aging
impacts the brain. However, a more granular systems-based approach, which considers the
impact of age on key features relating to neural processing, is required. Here, we review …